Reputable factory supply Gemcitabinehydrochloride 122111-03-9 in stock with high standard

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What is the Gemcitabine hydrochloride ?

Gemcitabine hydrochloride is White crystalline granular, odorless, while it's Molecular Formula is C9H11F2N3O4^.HCl. An antineoplastic

What is the CAS number for Gemcitabine hydrochloride ?

The CAS number of Gemcitabine hydrochloride is 122111-03-9.

More information of Gemcitabine hydrochloride 122111-03-9 are:

Synonyms	Gemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);
CAS Number	122111-03-9
Molecular Formula	C9H11F2N3O4^.HCl
Molecular Weight	299.662
Density	==
Melting Point	>250 °C dec
Boiling Point	482.7 °C at 760 mmHg
Flash Point	245.7 °C
HS CODE	29420000
PSA	110.60000
LogP	0.09460

What is Gemcitabine hydrochloride (122111-03-9) used for?

Gemcitabine is a novel nucleoside analog that was launched in 1995 in the Netherlands for the treatment of non-small cell lung cancer (nsclc) and in Sweden for pancreatic cancer. Gemcitabine is a prodrug which is phosphorylated intracellularly by deoxycytadine kinase to its active forms, the di- and triphosphates which bind to DNA competitively. This insertion inhibits processes required for DNA synthesis and metabolism, the essential function for both cell replication and repair. Furthermore, gemcitabine displays an extraordinary array of self-potentiating mechanisms that increase the concentration and prolong the retention of its active nucleotides in tumor cells. The title compound has shown activity against a wide spectrum of human solid tumors including colon, mammary, breast, bladder cancers. Synergistic activity of gemcitabine with other anticancer agents such as cisplatin has been reported.

InChI:InChI=1/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H

Articles related to Gemcitabine hydrochloride:

Article

Source

Synthesis and in vitro cytotoxic activity on human anaplastic thyroid cancer cells of lipoamino acid conjugates of gemcitabine

Pignatello, Rosario,Vicari, Luisa,Pistara, Venerando,Musumeci, Teresa,Gulisano, Massimo,Puglisi, Giovanni

, p. 294 - 302 (2010)

Stereoselective N-glycosylation with N4-acyl cytosines and efficient synthesis of gemcitabine

Liu, Tongchao,Tang, Jiadeng,Liang, Jianpeng,Chen, Yabin,Wang, Xiaowen,Shen, Jingkang,Zhao, Dongmei,Xiong, Bing,Cen, Jun-Da,Chen, Yue-Lei

, p. 1203 - 1213 (2019/01/29)

How to get the best price on Gemcitabine hydrochloride?

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