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Cytarabine is white or off-white crystalline powder, while it's Molecular Formula is C9H13N3O5. Cytarabine USP (Cytosar)is used to treat Acute granulocytic leukemia (adults); acute lymphocytic leukemia (children); Hodgkin’s disease
The CAS number of Cytarabine is 147-94-4.
More information of Cytarabine 147-94-4 are:
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Synonyms |
2(1H)-Pyrimidinone,4-amino-1-a-Darabinofuranosyl-;U-19,920;Cytosine Arabinoside;cytarbine;Depocyt (liposomal);Arafcyt;Cytosine, 1-beta-D-arabinofuranosyl-;Cytosine-1-beta-arabinofuranoside;Depocyt (TN);Cytosine beta-D-arabinofuranoside;Erpalfa;Arabitin;Tarabine PFS;ara-Cytosine;Cytarabin;1.beta.-D-Arabinofuranosylcytosine;Udicil;NCI-C04728;.beta.-Cytosine arabinoside;Cytosar U;Aracytin;1-(beta,D-Arabinofuranosyl)cytosine;Cyclocide;2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-;1beta-D-Arabinosylcytosine;Arabinofuranosylcytosine; |
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CAS Number |
147-94-4 |
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Molecular Formula |
C9H13N3O5 |
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Molecular Weight |
243.219 |
|
Density |
1.89 g/cm3 |
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Melting Point |
214 °C |
|
Boiling Point |
545.7 °C at 760 mmHg |
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Flash Point |
283.8 °C |
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HS CODE |
PRICE |
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PSA |
130.83000 |
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LogP |
-1.98180 |
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Pka |
pKa 4.3 (Uncertain) |
Cytarabine (147-94-4) is a nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells.1,2 Cellular enzymes convert it to its nucleotide form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it.3,4 For the same reasons, it is also employed as an antiviral.5 It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).6
InChI:InChI=1/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6+,7?,8-/m1/s1
Articles related to Cytarabine:
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Article |
Source |
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- |
Sanchez,Orgel , p. 531,536 (1970) |
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On the reaction of Vilsmeier-Haack reagent with nucleoside: a convenient synthesis of 2,2'-cyclocytidine. |
Kikugawa,Ichino , p. 867 - 870 (1970) |
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