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In terms of pharmacological parameters, prilocaine is comparable to lidocaine; however, because of a number of toxic manifestations, it is rarely used in medical practice. Citanest and xylonest are well-known synonyms for prilocaine.
propylamine
2-chloropropionyl chloride
o-toluidine
prilocaine
| Conditions | Yield |
|---|---|
|
2-chloropropionyl chloride; o-toluidine;
With
potassium carbonate;
In
acetone;
at 0 - 30 ℃;
for 5h;
propylamine;
In
acetone;
at 70 ℃;
for 14h;
|
97% |
propylamine
N-(2-methylphenyl)-2-chloropropanamide
prilocaine
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
acetone;
Reflux;
|
90% |
The CAS number of Prilocaine is 721-50-6.
More information of Prilocaine 721-50-6 are:
|
CAS Number |
721-50-6 |
|
Density |
1.029 g/cm3 |
|
Melting Point |
37-38oC |
|
Boiling Point |
361.6 °C at 760 mmHg |
|
Flash Point |
134.3 °C |
|
Refractive Index |
nD20 1.5298 |
|
HS CODE |
2924296000 |
|
PSA |
41.13000 |
|
LogP |
2.78550 |
|
Pka |
pKa 7.32 or 7.89 (Uncertain) |
Synonyms for Prilocaine 721-50-6:o-Propionotoluidide,2-(propylamino)- (6CI,8CI);2-Methyl-a-propylaminopropionanilide;Astra 1512;Astra 1515;Citanest;N-(2,6-Dimethylphenyl)-2-(propylamino)propanamide;NSC 40027;Propitocaine;o-Methyl-2-propylaminopropionanilide;
The chemical formula of Prilocaine is C13H20N2O which containing 13 Carbon atoms,20 Hydrogen atoms,2 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of Prilocaine is 220.315.
Prilocaine is an amino acid amide local anesthetic drug, chemically known as N-propyl-DL-alanine and 2-methylaniline, which forms an amide bond. It is a white or almost white, crystalline powder with a melting point of 37-38 ℃ and a boiling point of 159-162 ℃ (0.133kPa). Prilocaine hydrochloride is a water-soluble salt available as a solution for nerve block or infiltration in dental procedures. It is used for intravenous regional anesthesia due to its low risk of CNS toxicity because of quick metabolism. Prilocaine prepared in the crystal form is used in EMLA for topical administration to decrease painful needlesticks in children. The 4% solution should be protected from light, and the manufacturer recommends discarding if the solution turns pinkish or slightly darker than light yellow. Solutions are available in various concentrations up to 4%, with or without epinephrine and with or without preservatives.
InChI:InChI=1/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
Relevant articles related to Prilocaine:
|
Article |
Source |
|
A method for preparing prilocaine hydrochloride |
- Paragraph 0051; 0052, (2017/03/14) |
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