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What is the Estetrol ?

Estetrol is , while it's Molecular Formula is C18H24O4. A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.

What is the CAS number for Estetrol ?

The CAS number of Estetrol is 15183-37-6.

More information of Estetrol 15183-37-6 are:

Synonyms	Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15α,16α,17β)-;15a-Hydroxyestriol;(15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrol;(8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol;
CAS Number	15183-37-6
Molecular Formula	C18H24O4
Molecular Weight	304.386
Density	1.343 g/cm³
Melting Point	233-236°C
Boiling Point	491.9 °C at 760 mmHg
Flash Point	231.7 °C
PSA	80.92000
LogP	1.55080
Pka	10.22±0.70(Predicted)

What is Estetrol (15183-37-6) used for?

Estetrol, also known as E4, is an estrogen steroid hormone that is exclusively produced by the fetal liver from estradiol and estriol during pregnancy. It is characterized by its off-white solid appearance and has a unique binding affinity to estrogen receptors (ERs), with a 4-fold higher affinity for ERα over ERβ. Estetrol exhibits estrogenic effects in most tissues expressing ERs, such as bone, brain, vagina, and endometrium. Interestingly, in breast tumors, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.

InChI:InChI=1/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12?,13-,14?,15?,16?,17+,18+/m1/s1

Articles related to Estetrol:

Article

Source

Synthesis of 15α-hydroxyestrogen 15-N-acetylglucosaminides

Suzuki, Emako,Namba, Susumu,Kurihara, Hiroyuki,Goto, Junichi,Matsuki, Yasuhiko,Nambara, Toshio

, p. 277 - 284 (1995)

PROCESS FOR PREPARING (15ΑLPHA,16ΑLPHA,17ΒETA)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) AND INTERMEDIATES OF SAID PROCESS

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Page/Page column 14-15, (2021/04/02)

How to get the best price on Estetrol?

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