The utility of [18F]fluoromethyl tosylat...
Our recent investigations for the radios...
We developed a radiosynthesis of the vol...
Sequential usage of azide and MTBD, whic...
The present invention relates to a metho...
methylene ditosylate
![[18F]fluoromethylene toluene-4-sulfonate](/upload/2026/4/be7e5d09-0941-45e4-85c3-24e750d81b28.png)
[18F]fluoromethylene toluene-4-sulfonate
| Conditions | Yield |
|---|---|
|
With
potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA;
In
water; acetonitrile;
at 120 ℃;
for 0.166667h;
Inert atmosphere;
Sealed tube;
|
95% |
|
methylene ditosylate;
In
water; acetonitrile;
for 0.166667h;
With
tetrabutylammoniun azide;
at 80 ℃;
for 0.0833333h;
|
77% |
|
With
potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA;
In
water; acetonitrile;
at 105 ℃;
for 0.166667h;
Reagent/catalyst;
Inert atmosphere;
|
59% |
|
at 40 - 50 ℃;
|
10% |
|
With
carbonate(2-); [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA;
|
|
|
With
[18F]-potassium fluoride; potassium carbonate; [2.2.2]cryptande;
In
water; acetonitrile;
at 110 ℃;
for 0.166667h;
|
|
|
With
potassium carbonate; [2.2.2]cryptande;
In
acetonitrile;
at 100 ℃;
for 0.166667h;
|
|
|
With
18F-fluoride; caesium carbonate; [2.2.2]cryptande;
In
water; acetonitrile; tert-butyl alcohol;
at 100 - 150 ℃;
for 0.166667h;
ion exchange resin
Product distribution / selectivity;
|
|
|
With
18F-fluoride; caesium carbonate; [2.2.2]cryptande;
In
tert-Amyl alcohol; water; acetonitrile;
at 100 - 150 ℃;
for 0.166667h;
ion exchange resin
Product distribution / selectivity;
|
|
|
With
[18F]-potassium fluoride; potassium carbonate; [2.2.2]cryptande;
In
water; acetonitrile;
at 110 ℃;
for 0.166667h;
Inert atmosphere;
|
|
|
With
18-crown-6 ether; potassium carbonate; [18F]fluoride ion, cyclotron produced, NCA;
In
acetonitrile;
at 100 ℃;
Inert atmosphere;
|
|
|
With
18-crown-6 ether; potassium carbonate; [18F]fluoride ion, cyclotron produced, NCA;
In
water; acetonitrile;
at 100 ℃;
|
|
|
With
18-crown-6 ether; potassium carbonate; [18F]fluoride ion, cyclotron produced, NCA;
In
water; acetonitrile;
at 100 ℃;
|
|
|
With
[18F]-potassium fluoride; [2.2.2]cryptande;
In
water; acetonitrile;
at 110 ℃;
for 0.166667h;
|
bis(4-methylphenylsulfonyl)methane
[18F]fluoromethylene toluene-4-sulfonate
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
acetonitrile;
at 110 ℃;
for 0.0833333h;
|
methylene ditosylate
bis(4-methylphenylsulfonyl)methane
silver(I) 4-methylbenzenesulfonate
[18F]FCH
N-(2-chloro-5-(S-2-[18F]fluoromethyl)thiophenyl)-N'-(3-methylthiophenyl)-N'-methyl-guanidine
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