


The Wacker-Tsuji aerobic oxidation of va...
The invention relates to the field of ch...
The invention provides a preparation met...
The present invention relates to a proce...
(R)-2-methylamino-1-phenylpropane
propargyl bromide
SELEGILINE
| Conditions | Yield |
|---|---|
|
With
tetrabutylammomium bromide; potassium carbonate;
In
water; toluene;
for 24h;
Ambient temperature;
|
82% |
|
With
potassium carbonate;
In
acetonitrile;
at 25 ℃;
for 12h;
|
72% |
|
With
potassium carbonate;
In
acetonitrile;
at 25 ℃;
for 3h;
|
71% |
|
With
potassium carbonate;
In
acetonitrile;
at 50 ℃;
|
66.8% |
(R)-2-N-methylamino-1-phenylpropane hydrochloride
propargyl bromide
SELEGILINE
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
toluene; acetonitrile;
at 20 ℃;
for 3h;
enantioselective reaction;
|
85% |
methamphetamin
2-propynyl chloride
1-phenyl-acetone
allylbenzene
(-)-N,1-dimethyl-N-propargylphenylethylamine
C19H26N4O4
(R)-(-)-deprenyl hydrochloride