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Flibanserin is white powder, while it's Molecular Formula is C20H21F3N4O. Antidepressant (5-HT1a agonist and 5-HT2 antagonist).
The CAS number of Flibanserin is 167933-07-5.
More information of Flibanserin 167933-07-5 are:
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Synonyms |
1-(2-(4-(3-Trifluoromethylphenyl)piperazin-1-yl)ethyl)benzimidazol(1H)-2-one;Bimt 17;1,3-Dihydro-1-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-2H-benzimidazol-2-one;1-(2-(4-alpha,alpha,alpha-Trifluoro-m-tolyl)-1-piperazinyl)ethyl)-2-benzimidazolinone;Bimt-17; |
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CAS Number |
167933-07-5 |
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Molecular Formula |
C20H21F3N4O |
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Molecular Weight |
390.408 |
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Density |
1.292 g/cm3 |
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PSA |
44.27000 |
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LogP |
3.17350 |
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Pka |
12.12±0.30(Predicted) |
Flibanserin is a drug originally developed by Boehringer-Ingelheim and later Sprout Pharmaceuticals, which was approved in 2015 by the FDA for the treatment of premenopausal women with hypoactive sexual desire disorder (HSDD). The drug, which was originally developed for the treatment of depression by Boehringer- Ingelheim, is a full agonist of the 5-HT1A receptor, an antagonist of the 5-HT2A receptor, and a partial agonist of the dopamine-4 (D4) receptor, which triggers increased dopamine and norepinephrine levels along with decreased serotonin levels. In three randomized trials involving 2400 premenopausal women, the drug was found to increase the number of satisfying sexual events by 0.5-1.0 events per month and increased sexual desire on average by 10-12% over placebo. Side effects include decreased blood pressure and loss of consciousness, especially in subjects who consumed alcohol.
InChI:InChI=1/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
Articles related to Flibanserin:
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Article |
Source |
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Synthetic method of flibaserin |
- Paragraph 0038-0039; 0041; 0043-0044; 0046-0047; 0049-0050, (2021/09/21) |
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Preparation method of Flibanserin intermediate |
- , (2019/03/15) |
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