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A mu-opioid receptor agonist
Z-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
dermorphin
| Conditions | Yield |
|---|---|
|
With
formic acid; palladium;
|
80% |
N-(fluoren-9-ylmethoxycarbonyl)glycine
Fmoc-Pro-OH
N-Fmoc L-Phe
Fmoc-Ser(tBu)-OH
Fmoc-Tyr(tBu)-OH
N-(9-fluorenylmethoxycarbonyl)-D-alanine
dermorphin
| Conditions | Yield |
|---|---|
|
Fmoc-Ser(tBu)-OH;
With
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine;
In
1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
With
piperidine;
In
1-methyl-pyrrolidin-2-one;
for 0.333333h;
N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Pro-OH; N-Fmoc L-Phe; Fmoc-Tyr(tBu)-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine;
Further stages;
|
The CAS number of DERMORPHIN ACETATE is 77614-16-5.
More information of DERMORPHIN ACETATE 77614-16-5 are:
|
CAS Number |
77614-16-5 |
|
Density |
1.363g/cm3 |
|
Melting Point |
157-159 °C |
|
Boiling Point |
1323.8°C at 760 mmHg |
|
Flash Point |
754.4°C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.628 |
|
PSA |
314.05000 |
|
LogP |
3.98630 |
|
Pka |
9.83±0.15(Predicted) |
Synonyms for DERMORPHIN ACETATE 77614-16-5:H-Tyr-D-ala-phe-gly-tyr-pro-ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;Dermorphin;
The chemical formula of DERMORPHIN ACETATE is C40H50N8O10 which containing 40 Carbon atoms,50 Hydrogen atoms,8 Nitrogen atoms and 10 Oxygen atoms,and the molecular weight of DERMORPHIN ACETATE is 802.885.
InChI:InChI=1/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
Relevant articles related to DERMORPHIN ACETATE:
|
Article |
Source |
|
Iodotrichlorosilane as Nα-Z cleaving agent in solid phase synthesis of dermorphin and oxytocin |
Sivanandaiah, K. M.,Babu, V. V. Suresh,Renukeshwar, H. C.,Gangadhar, B. P. , p. 487 - 491 (2007/10/02) |
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