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Fludarabine phosphate is , while it's Molecular Formula is C10H13FN5O7P. Fludarabine phosphate is used for the treatment of chronic lymphatic leukemia and low-grade lymphoma. In the circulation,fludarabine phosphate is immediately dephosphorylated to the nucleoside fludarabine. About 30-40% of nucleoside fludarabine is excreted into the urine. In addition, fludarabine is metabolized into a hypoxanthine metabolite also excreted in the urine.Intracellularly,fludarabine is stepwise rephosphorylated to the active triphosphate. Deoxycytidine kinase is the dominant, if not the exclusive,enzyme for the formation of the monophosphate. Adenylate kinase and nucleoside diphosphate kinase are believed to be involved in the formation of the diphosphate and triphosphate,respectively.
The CAS number of Fludarabine phosphate is 75607-67-9.
More information of Fludarabine phosphate 75607-67-9 are:
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Synonyms |
Fludarabine phosphate (JAN/USP);Fludarabine 5-monophosphate;9-beta-D-Arabinofuranosyl-2-fluoroadenine 5-(dihydrogen phosphate);Trimeric Sodium Phosphate;[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid;2-Fluoro-ARA AMP;Fludarabine phosphate [USAN:BAN];Fludarabine monophosphate;9-beta-Arabinofuranosyl-2-fluoroadenine-5-phosphate;Fludura;9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-;2-Fluoroadenine arabinoside 5-monophosphate;fludarabine hcl; |
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CAS Number |
75607-67-9 |
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Molecular Formula |
C10H13FN5O7P |
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Molecular Weight |
365.215 |
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Density |
2.39 g/cm3 |
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Melting Point |
203°C(dec.)(lit.) |
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Boiling Point |
864.2 °C at 760 mmHg |
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Flash Point |
476.4 °C |
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HS CODE |
2934990002 |
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PSA |
195.88000 |
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LogP |
-1.14270 |
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Pka |
1.86±0.10(Predicted) |
Fludarabine phosphate is an antimetabolite indicated for the treatment of B cell lymphocytic leukemia. It is reportedly effective in patients refractory to other therapies. Fludarabine phosphate acts by inhibiting primer RNA synthesis. Its side effects include bone marrow suppression, anemia, thrombocytopenia and neutropenia.
InChI:InChI=1/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1
Articles related to Fludarabine phosphate:
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Article |
Source |
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Synthesis method of fludarabine phosphate |
- Paragraph 0041-0043; 0061-0065, (2020/08/22) |
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Fludarabine phosphate preparation method |
- Paragraph 0009, (2017/01/26) |
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