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Finasteride, a novel 4-azasteroid, is a breakthrough in the treatment and control of benign prostatic hyperplasia. Mechanistically, it inhibits the prostatic-specific enzyme 5-alpha reductase, thereby decreasing the conversion of testosterone to dihydrotestosterone. It is reportedly effective in reducing urinary symptoms and prostatic volume and increasing maximal urinary flow rate. Finasteride is also being investigated as a treatment for prostatic cancer.
Finasteride (Proscar) is a 5-reductase inhibitor that blocks the conversion of testosterone to DHT in target tissues. Since DHT is the major intracellular androgen in the prostate, finasteride is effective in suppressing DHT stimulation of prostatic growth and secretory function without markedly affecting libido. It is approved for the treatment of benign prostatic hyperplasia. Although there is usually some regression in the size of the prostate gland following administration of finasteride, clinical response may take 6 to 12 months. If the obstructive symptoms are severe, there is often not enough time to allow Finasteride to work.The principal adverse effects of finasteride are impotence, decreased libido, and decreased volume of ejaculate. The compound is generally well tolerated in men.
Finasteride is an antialopecia agent that Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. It is used to treatment of benign prostatic hyperplasia and androgenetic alopecia.
The CAS number of Finasteride is 98319-26-7.
More information of Finasteride 98319-26-7 are:
|
CAS Number |
98319-26-7 |
|
Density |
1.065 g/cm3 |
|
Melting Point |
253 °C |
|
Boiling Point |
576.6 °C at 760 mmHg |
|
Flash Point |
177.4 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.524 |
|
HS CODE |
29379000 |
|
PSA |
58.20000 |
|
LogP |
4.53420 |
|
Pka |
14.17±0.70(Predicted) |
The chemical formula of Finasteride is C23H36N2O2 which containing 23 Carbon atoms,36 Hydrogen atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of Finasteride is 372.551
Finasteride, a novel 4-azasteroid, is a breakthrough in the treatment and control of benign prostatic hyperplasia. Mechanistically, it inhibits the prostatic-specific enzyme 5-alpha reductase, thereby decreasing the conversion of testosterone to dihydrotestosterone. It is reportedly effective in reducing urinary symptoms and prostatic volume and increasing maximal urinary flow rate. Finasteride is also being investigated as a treatment for prostatic cancer.
InChI:InChI=1/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18?,22-,23+/m0/s1
Relevant articles related to Finasteride:
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Article |
Source |
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Refining and decolorizing method of finasteride |
- Paragraph 0025-0038, (2019/10/01) |
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