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AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in vascular disease.3 ?Induces osteogenic differentiation in mesenchymal stem cells.4 Inhibits proinflammatory response in glial cells.5 Cell permeable.
5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
The CAS number of AICAR is 2627-69-2.
More information of AICAR 2627-69-2 are:
|
CAS Number |
2627-69-2 |
|
Density |
2.06 g/cm3 |
|
Melting Point |
214-215 °C |
|
Boiling Point |
726.3 °C at 760 mmHg |
|
Flash Point |
393.1 °C |
|
Vapor Pressure |
3.83E-22mmHg at 25°C |
|
Refractive Index |
1.821 |
|
HS CODE |
29349990 |
|
PSA |
156.85000 |
|
LogP |
-1.54280 |
|
Pka |
13.27±0.70(Predicted) |
The chemical formula of AICAR is C9H14N4O5 which containing 9 Carbon atoms,14 Hydrogen atoms,4 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight, and the molecular weight of AICAR is 258.234
AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in vascular disease.3 ?Induces osteogenic differentiation in mesenchymal stem cells.4 Inhibits proinflammatory response in glial cells.5 Cell permeable.
InChI:InChI=1/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
Relevant articles related to AICAR:
|
Article |
Source |
|
Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase |
Firestine, Steven M.,Wu, Weidong,Youn, Hasik,Jo Davisson , p. 794 - 803 (2009) |
|
IMPROVEMENTS TO ANALOGOUS COMPOUNDS OF 6-THIOGUANOSINE TRIPHOSPHATE, THEIR USE IN MEDICAL FIELDS AND PROCESSES FOR THEIR PREPARATION |
- Page/Page column 65, (2008/06/13) |
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