Aicar

  • CasNo:2627-69-2
  • Purity:
  • Molecular Formula:C9H14N4O5
  • Molecular Weight:258.234
  • Melting Point: 214-215 °C 
  • Apply:
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1.What is the AICAR ?

AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in vascular disease.3 ?Induces osteogenic differentiation in mesenchymal stem cells.4 Inhibits proinflammatory response in glial cells.5 Cell permeable.

5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

2.What is the CAS number for AICAR ?

The CAS number of AICAR is 2627-69-2.

More information of AICAR 2627-69-2 are:

CAS Number

2627-69-2

Density

2.06 g/cm3

Melting Point

214-215 °C

Boiling Point

726.3 °C at 760 mmHg

Flash Point

393.1 °C

Vapor Pressure

3.83E-22mmHg at 25°C

Refractive Index

1.821

HS CODE

29349990

PSA

156.85000

LogP

-1.54280

Pka

13.27±0.70(Predicted)

3.What is the molecular formula of AICAR ?

The chemical formula of AICAR is C9H14N4O5 which containing 9 Carbon atoms,14 Hydrogen atoms,4 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight, and the molecular weight of AICAR is 258.234

4.What is AICAR(2627-69-2)used for?

AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in vascular disease.3 ?Induces osteogenic differentiation in mesenchymal stem cells.4 Inhibits proinflammatory response in glial cells.5 Cell permeable.

InChI:InChI=1/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1

Relevant articles related to AICAR:

Article

Source

Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase

Firestine, Steven M.,Wu, Weidong,Youn, Hasik,Jo Davisson

, p. 794 - 803 (2009)

IMPROVEMENTS TO ANALOGOUS COMPOUNDS OF 6-THIOGUANOSINE TRIPHOSPHATE, THEIR USE IN MEDICAL FIELDS AND PROCESSES FOR THEIR PREPARATION

-

Page/Page column 65, (2008/06/13)

5.Chinese Factory Supply Wholesale Aicar 2627-69-2 with Cheap Price

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