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6-Ethylchenodeoxycholic Acid is a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease.
The CAS number of Obeticholic Acid is 459789-99-2.
More information of Obeticholic Acid 459789-99-2 are:
|
CAS Number |
459789-99-2 |
|
Density |
1.091 g/cm3 |
|
Melting Point |
108-110 °C |
|
Boiling Point |
562.9 °C at 760 mmHg |
|
Flash Point |
308.3 °C |
|
Vapor Pressure |
5.16E-15mmHg at 25°C |
|
Refractive Index |
1.529 |
|
HS CODE |
2918199890 |
|
PSA |
77.76000 |
|
LogP |
5.11400 |
|
Pka |
4.76±0.10(Predicted) |
Synonyms for Obeticholic Acid 459789-99-2:6α-ethyl-chenodeoxycholic acid;6-Ethyl-CDCA;
The chemical formula of Obeticholic Acid is C26H44O4 which containing 26 Carbon atoms,44 Hydrogen atoms and 4 Oxygen atoms,and the molecular weight of Obeticholic Acid is 420.63.
Obeticholic acid is a potent and selective farnesoid X receptor agonist that promotes the flow of bile in the liver. The drug was approved by the USFDA for the treatment of the rare chronic liver disease primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with inadequate response to UDCA or as a single agent therapy in adults unable to tolerate UDCA. Obeticholic acid was discovered at the Università de Perugia and developed by Intercept Pharmaceuticals. Obeticholic acid has also been granted orphan drug designation for the treatment of primary sclerosing cholangitis and primary biliary cirrhosis and has received breakthrough therapy designation for the treatment of patients with nonalcohol steatohepatitis (NASH) with liver fibrosis.
InChI:InChI=1/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
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