Obeticholic Aci

  • CasNo:459789-99-2
  • Purity:
  • Molecular Formula:C26H44O4
  • Molecular Weight:420.63
  • Melting Point: 108-110 °C 
  • Apply:
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1.What is the Obeticholic Acid ?

6-Ethylchenodeoxycholic Acid is a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease.

2.What is the CAS number for Obeticholic Acid ?

The CAS number of Obeticholic Acid is 459789-99-2.

More information of Obeticholic Acid 459789-99-2 are:

CAS Number

459789-99-2

Density

1.091 g/cm3

Melting Point

108-110 °C

Boiling Point

562.9 °C at 760 mmHg

Flash Point

308.3 °C

Vapor Pressure

5.16E-15mmHg at 25°C

Refractive Index

1.529

HS CODE

2918199890

PSA

77.76000

LogP

5.11400

Pka

4.76±0.10(Predicted)

3.What are another words for Obeticholic Acid ?

Synonyms for Obeticholic Acid 459789-99-2:6α-ethyl-chenodeoxycholic acid;6-Ethyl-CDCA;

4.What is the molecular formula of Obeticholic Acid?

The chemical formula of  Obeticholic Acid is C26H44O4 which containing 26 Carbon atoms,44 Hydrogen atoms and 4 Oxygen atoms,and the molecular weight of  Obeticholic Acid is 420.63.

5.What is Obeticholic Acid (459789-99-2) used for?

Obeticholic acid is a potent and selective farnesoid X receptor agonist that promotes the flow of bile in the liver. The drug was approved by the USFDA for the treatment of the rare chronic liver disease primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with inadequate response to UDCA or as a single agent therapy in adults unable to tolerate UDCA. Obeticholic acid was discovered at the Università de Perugia and developed by Intercept Pharmaceuticals. Obeticholic acid has also been granted orphan drug designation for the treatment of primary sclerosing cholangitis and primary biliary cirrhosis and has received breakthrough therapy designation for the treatment of patients with nonalcohol steatohepatitis (NASH) with liver fibrosis.

InChI:InChI=1/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1

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