What is the 1,8-DIAMINO-P-MENTHANE?

1,8-DIAMINO-P-MENTHANE is dark coloured liquid, while it's Molecular Formula is C10H22 N2. dark coloured liquid 1,8-Diamino-p-menthane is generally used in the synthesis of various Schiff bases that are used in the preparation of coordination complexes with Cu(II), Zn(II), Cr(III), Fe(III) and Co(III) ions. It is also used as a precursor to synthesize heterocyclic Schiff base derivatives with herbicidal activity.

What is the CAS number for 1,8-DIAMINO-P-MENTHANE?

The CAS number of 1,8-DIAMINO-P-MENTHANE is 80-52-4.

What is 1,8-DIAMINO-P-MENTHANE (80-52-4) used for?

1,8-Diamino-p-menthane is a primary alicyclic diamine and a tert-alkylamine, characterized as a dark-colored liquid. It is a versatile chemical intermediate with a wide range of applications across different industries.InChI:InChI=1/C10H20.2H3N/c1-8(2)10-6-4-9(3)5-7-10;;/h8-10H,4-7H2,1-3H3;2*1H3

1,8?Diamino?p?menthane Good Supplier In Bulk Supply High Purity 80-52-4

Molecular Formula:C10H22 N2
Molecular Weight:170.298
Appearance/Colour:dark coloured liquid
Vapor Pressure:10 mm Hg ( 20 °C)
Melting Point:?45 °C(lit.)
Refractive Index:n20/D 1.4805(lit.)
Boiling Point:107-126 °C10 mm Hg(lit.)
PKA:11.02±0.70(Predicted)
Flash Point:200 °F
PSA：52.04000
Density:0.914 g/mL at 25 °C(lit.)
LogP:3.03190

1,8-DIAMINO-P-MENTHANE(Cas 80-52-4) Usage

Air & Water Reactions	Slightly water soluble .
Reactivity Profile	1,8-DIAMINO-P-MENTHANE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Hazard	Strong irritant to eyes and skin, calls for eye protection.
Fire Hazard	1,8-DIAMINO-P-MENTHANE is combustible.
General Description	1,8-DIAMINO-P-MENTHANE is a chemical compound used as a precursor in the synthesis of alkylating β-blockers, specifically in the study of N-(bromoacetyl)-N'-[3-(o-allylphenoxy)-2-hydroxypropyl]-1,8-diamino-p-menthane (BAAM) isomers. It plays a role in the development of affinity labeling ligands for β-adrenoceptors, with certain configurations (e.g., 2-1 isomer) demonstrating high affinity and irreversible binding to these receptors in rat heart and lung tissues. 1,8-DIAMINO-P-MENTHANE's structural features contribute to the pharmacological activity of its derivatives, making it relevant for biochemical and receptor-binding studies.
Definition	A primary alicyclic diamine, also a tert-alkylamine.

InChI:InChI=1/C10H20.2H3N/c1-8(2)10-6-4-9(3)5-7-10;;/h8-10H,4-7H2,1-3H3;2*1H3

80-52-4 Relevant articles

Method for preparing 1 and 8 - P-menthane diamine from 1 and 8 - P-menthane diethanolamide

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Paragraph 0007; 0021; 0036-0063, (2021/03/03)

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Paragraph 0040-, (2021/08/06)

The invention provides a method for prep...

Synthesis and Herbicidal Activities of p-Menth-3-en-1-amine and Its Schiff Base Derivatives

Zhu, Shouji,Xu, Shichao,Jing, Wang,Zhao, Zhendong,Jiang, Jianxin

, p. 9702 - 9707 (2017/01/06)

p-Menth-3-en-1-amine, 4, and its Schiff ...

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Paragraph 0041-0042, (2017/06/02)

The invention discloses a method for pre...

80-52-4 Process route

: 80-53-5,89923-77-3
terpin hydrate

: 80-52-4
1,8-diamino-p-menthane

Conditions

Conditions	Yield
With sulfuric acid; sodium isocyanate; In water; at 0 - 50 ℃; for 12h; Reagent/catalyst;	96%

: 64374-26-1
N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide

: 80-52-4
1,8-diamino-p-menthane

Conditions

Conditions	Yield
With sodium hydroxide; In ethylene glycol; at 170 ℃; for 13h;
With sodium hydroxide; In ethylene glycol; for 13h; Solvent; Reflux;	81.9 %Chromat.
With sodium hydroxide; In butan-1-ol; at 175 ℃; for 18h; under 11251.1 Torr; Reagent/catalyst; Temperature; Time; Solvent; Pressure; Sealed tube; Inert atmosphere;